What can be said about the relationship between serum and clotting factors?

Serum is the liquid portion of blood that remains after coagulation has occurred, which means that it does not contain any clotting factors. This is an important characteristic because during the clotting process, factors such as fibrinogen are converted into fibrin, which forms the structure of a blood clot. Once clotting occurs, the clotting factors are consumed in the process, leaving the serum devoid of these components.

In contrast, plasma, which is the liquid part of blood that has not undergone clotting, contains all the clotting factors. Understanding the distinction between serum and plasma is crucial in phlebotomy and various laboratory settings, as it impacts the types of tests performed and the interpretation of results.